Agent Name

2-Chloro-1-propanol

Alternative Name

Propylene chlorohydrin

CAS Number

78-89-7

Formula

C3-H7-Cl-O

Major Category

Other Classes

Synonyms

Propylene chlorohydrin; 1-Hydroxy-2-chloropropane; 1-Propanol, 2-chloro-; 2-Chloropropanol; 2-Chloropropyl alcohol; Propylenechlorohydrin; beta-Chloropropyl alcohol; [ChemIDplus]

Category

Halogenated Alcohols

Description

Colorless liquid with a pleasant odor; [Merck Index]

Sources/Uses

Used in organic synthesis; [Hawley] Used to make propylene oxide; [HSDB] Produced as residue on foods when fumigated with propylene oxide; [WHO] A constituent of technical grade 1-chloro-2-propanol at 25%; [ACGIH]

Comments

External application to rabbit eyes scored 8 on a scale of 1-10 (10 being most severe) for degree of injury after 24 hours; Rats exposed 15 times to six hours of inhalation at 250 ppm displayed lung congestion and perivascular edema; Decreased body weights and histopathology in the acinar cells of the pancreas were the only observations in high-dose animal feeding studies; [HSDB] General anesthetic effect in lethal-dose feeding studies of guinea pigs; [RTECS] A skin and severe eye irritant; May cause hemolysis; [CAMEO] See "1-Chloro-2-propanol."

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

1 ppm

Vapor Pressure

5.25 mm Hg

Lethal Concentration

LCLo (rat) > 500 ppm/4h

Explanatory Notes

Flash point = 51.6 deg C; [Hawley]

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: