Agent Name

Ethohexadiol

Alternative Name

2-Ethyl-1,3-hexanediol

CAS Number

94-96-2

Formula

C8-H18-O2

Major Category

Other Classes

Synonyms

2-Ethyl-1,3-hexanediol; 2-Ethyl-1,3-hexylene glycol; 2-Ethyl-3-propyl-1,3-propanediol; 3-Hydroxymethyl-n-heptan-4-ol; 6-12; 6-12 insect repellent; 6-12-Insect repellent; Carbide 6-12; Compound 6-12 insect repellent; Diol-Kyowa 8; Latka 612 [Czech]; Octylene glycol; Repellent 612; Rutgers 612; [ChemIDplus]

Category

Alcohols and Polyols, Other

Description

Colorless, odorless, hygroscopic liquid; [Hawley]

Sources/Uses

Used as a solvent for resins; as a plasticizer; as a chemical intermediate in the production of polyurethane resins; as an insect repellent; in cosmetics; as a vehicle and solvent in printing inks; in medicines; as a chelating agent for boric acid; [HSDB]

Comments

A moderate eye and mucous membrane irritant; Skin absorption may cause CNS depression; [HSDB] Produces birth defects when given to rats in high doses; No data on human exposure; [REPROTOX] Effects in high-dose animal studies include ataxia, somnolence, and liver changes; [RTECS] An irritant; May cause serious injury to eyes; May be absorbed through skin; [MSDSonline]

Restricted

Except for cosmetics, voluntarily removed from US and Canadian markets in 1991 after high-dose animal experiment showed poor lung expansion in offspring; [REPROTOX]

Exposure Assessment
Lethal Concentration

LC (rat) > 4,800 ppm/8h

Explanatory Notes

Flash point = 127 deg C; VP < 0.01 mm at 20 deg C; [Merck Index]

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: