Agent Name

Lactonitrile

Alternative Name

2-Hydroxypropanenitrile

CAS Number

78-97-7

Formula

C3-H5-N-O

Major Category

Nitrogen Compounds

Synonyms

2-Hydroxypropanenitrile; 2-Hydroxypropannitril [Czech]; 2-Hydroxypropionitrile; Acetaldehyde, cyanohydrin; Acetocyanohydrin; Ethylidene cyanohydrin; Laktonitril [Czech]; Propanenitrile, 2-hydroxy-; Propionitrile, 2-hydroxy-; alpha-Hydroxypropionitrile; [ChemIDplus]

Category

Nitriles

Description

Straw-colored liquid; [Hawley] Yellow to orange liquid; [MSDSonline]

Sources/Uses

Used as a solvent and to make ethyl lactate and lactic acid; [Hawley] Used as an intermediate for the production of alanine, acrylic fibres, resins, and acrylic acid; [eChemPortal: SIDSUNEP]

Comments

An eye irritant; Highly toxic by eye contact, ingestion, and skin absorption; Emergency treatment: "Lactonitrile"; May cause cyanide poisoning after a delay of several hours; An oral dose of >10 mg/kg is lethal in animals, as is 0.05 ml applied to the eye and 1 mg/kg applied to the skin; [HSDB] Hepatotoxic in animal testing with a NOEL = 6 mg/kg/day; [Reference #1] May cause irritation; Readily absorbed through skin (may be fatal); [Aldrich MSDS] See "NITRILES."

Reference Link

OECD SIDS: 2-Hydroxypropanenitrile - 1994

Exposure Assessment
Vapor Pressure

0.11 mm Hg

Lethal Concentration

LCLo (rat) = 125 ppm/4h

Explanatory Notes

Flash point = 76.6 deg C; [Hawley]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Chemical Asphyxiant

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: