Agent Name

2-Methoxy-1,4-benzenediamine

CAS Number

5307-02-8

Formula

C7-H10-N2-O

Major Category

Nitrogen Compounds

Synonyms

1,4-Benzenediamine, 2-methoxy-; 2,5-Diaminoanisole; 2-Methoxy-p-phenylenediamine; 2-MPPD; p-Diaminoanisole; p-Phenylenediamine, 2-methoxy-; [ChemIDplus]

Category

Amines, Aromatic

Sources/Uses

Used as a component in hair dyes; [HSDB]

Comments

Reproductive effects in 8-week IP study with rats include decrease in number of pregnancies and live fetuses; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] See "p-Phenylenediamine."

Exposure Assessment
Vapor Pressure

0.00132 mm Hg

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

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Health Studies

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Chemical Information

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Diseases

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Processes

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