Agent Name

2-Picoline

CAS Number

109-06-8

Formula

C6-H7-N

Major Category

Nitrogen Compounds

Synonyms

alpha-Picoline; 2-Methylpyridine; AI3-24109; PICOLINE, ALPHA; Picoline; Pyridine, 2-methyl-; alpha-Methylpyridine; o-Picoline; [ChemIDplus] UN2313

Category

Pyridines

Description

Colorless liquid with a strong unpleasant odor; [Hawley] Colorless or yellow tinted clear liquid; [MSDSonline]

Sources/Uses

Used as an intermediate (dyes, resins, agrochemicals, and pharmaceuticals), solvent, and laboratory reagent; [HSDB] Found naturally in coal tar; Used as a solvent and to make dyes and resins; [MSDSonline] Picolines are constituents in cigarette smoke, bone oil, coal tar, and coke oven emissions. [AIHA]

Comments

A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation of high concentrations can cause unconsciousness; The liquid defats the skin; [ICSC] An irritant; Harmful if swallowed, inhaled, or absorbed through skin; A strong respiratory tract irritant; May cause convulsions; Oral LD50 (rat) = 790 mg/kg; [MSDSonline] An irritant that can cause CNS depression; Liver changes occur in rats exposed to chronic high doses; [AIHA] See "Pyridine."

Exposure Assessment
WEEL

2 ppm, STEL = 5 ppm

Vapor Pressure

11.2 mm Hg

Odor Threshold Low

0.01 ppm

Odor Threshold High

0.45 ppm

Lethal Concentration

LCLo (rat) = 4,000 ppm/4h

Explanatory Notes

Flash point = 26 deg C; [ICSC] Odor threshold low = 0.05 mg/m3; High = 0.17 mg/m3; [HSDB] The Guide in the Emergency Response Guidebook is for "Picolines."

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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