Agent Name

2-Naphthol

Alternative Name

beta-Naphthol

CAS Number

135-19-3

Formula

C10-H8-O

Major Category

Other Classes

Synonyms

beta-Naphthol; 2-Hydroxynaphthalene; 2-Naftol [Dutch]; 2-Naftolo [Italian]; 2-Naphthalenol; 2-Naphtol [French]; Azogen Developer A; Betanaphthol; C.I. 37500; C.I. Azoic Coupling Component 1; C.I. Developer 5; Developer A; Developer AMS; Developer BN; Developer sodium; Isonaphthol; NAPHTHOL, BETA; Naphthol B; beta-Hydroxynaphthalene; beta-Monoxynaphthalene; beta-Naftol [Dutch]; beta-Naftolo [Italian]; beta-Naphthol; beta-Naphthyl alcohol; beta-Naphthyl hydroxide; beta-Naphtol [German]; beta-Napthol; [ChemIDplus] UN3077

Category

Naphthols

Description

White solid; Darkens upon aging and exposure to sunlight; [Hawley] Tan chips with a phenol-like odor; [MSDSonline]

Sources/Uses

Used to make dyes, pigments, fungicides, insecticides, pharmaceuticals, and perfumes; Also used as antioxidants for rubber, fats, and oils; as an antiseptic; for lubrication of steam turbines, electric motors, hydraulic equipment, and instruments; and formerly as an anthelmintic; [HSDB] Also used as an additive in electroplating, developer in dyeing and printing of fabrics, in tanneries, and in the paints-lacquers-varnishes industry; [IUCLID]

Comments

A severe eye irritant; May cause skin sensitization; "The substance may have effects on the kidneys, blood and eyes, resulting in kidney impairment, anaemia and lens opacities." [ICSC] Emergency medical treatment: see "Phenol." [HSDB] Causes diarrhea, impaired motility, and corneal opacities in lethal-dose animal studies; A skin sensitizer in guinea pig testing and in a study of workers; Causes liver and kidney injury after repeated administration to animals; [Reference #1] An irritant; May cause injury to eyes; May be absorbed through skin resulting in kidney injury; [MSDSonline]

Reference Link

OECD SIDS: 2-Naphthol - 2002

Exposure Assessment
Odor Threshold Low

0.01 ppm

Odor Threshold High

11.4 ppm

Lethal Concentration

LC50 (rat) = 2,200 mg/m3/4h

Explanatory Notes

Flash point = 152.7 deg C; [Hawley] VP = 9.9 mm Hg at 144 deg C; [HSDB] Odor threshold from HSDB; The Guide in the Emergency Response Guidebook is for "Environmentally hazardous substances, solid, n.o.s."

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: