Agent Name

Bromoform

Alternative Name

Tribromomethane

CAS Number

75-25-2

Formula

C-H-Br3

Major Category

Solvents

Synonyms

Bromoform; Bromoforme [French]; Bromoformio [Italian]; Methane, tribromo-; Methenyl tribromide; Methyl tribromide; Tribrommethaan [Dutch]; Tribrommethan [German]; Tribromometan [Italian]; Tribromomethane; [ChemIDplus] UN2515

Category

Brominated Solvents

Description

Colorless to yellow liquid with a chloroform-like odor; Note: A solid below 47 degrees F; [NIOSH]

Sources/Uses

Used as a intermediate for pharmaceuticals and other organic compounds; also used as a solvent for waxes and oils; [ACGIH]

Comments

Narcosis and liver injury occur in animal studies; Workers complain of irritating effects to the eyes, throat, and respiratory tract; [ACGIH] A lachrymator; [CHEMINFO] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC]

Reference Link

NIOSH Occupational Health Guidelines for Chemical Hazards: Bromoform

Exposure Assessment
Skin Designation (ACGIH)

No

TLV (ACGIH)

0.5 ppm

PEL (OSHA)

0.5 ppm

IDLH (NIOSH)

850 ppm

Excerpts from Documentation for IDLHs

It has been reported that 14,000 to 16,000 ppm will cause rapid loss of consciousness [Patty 1963].

Vapor Pressure

5 mm Hg

Odor Threshold Low

0.19 ppm

Odor Threshold High

15 ppm

Lethal Concentration

LCLo (rat) = 45,000 mg/m3/4H

Explanatory Notes

Odor threshold from AIHA;

Half Life

Whole body (animal studies): 4 hours; [TDR, p. 220]

Reference Link

ATSDR - ToxFAQs - Bromoform and Dibromochloromethane

Adverse Effects
Lacrimator

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: