Agent Name

3,3',4,4'-Tetrachlorobiphenyl

CAS Number

32598-13-3

Formula

C12-H6-Cl4

Major Category

Other Classes

Synonyms

1,1'-Biphenyl, 3,3',4,4'-tetrachloro-; 3,3',4,4'-Tetrachloro-1,1'-biphenyl; 3,4,3',4'-Tetra coplanar polychlorinated biphenyl; 3,4,3',4'-Tetrachlorobiphenyl; 4-CB; Biphenyl, 3,3',4,4'-tetrachloro-; PCB 77; [ChemIDplus] UN2315

Category

Halogenated Polyaromatics

Description

White solid; [MSDSonline]

Sources/Uses

Found in commercial PCBs, their manufacturing facilities, and during destruction or degradation of products containing PCBs; [HSDB]

Comments

Emergency medical treatment: see PCB-PBB; A skin and eye irritant; Evidence of reproductive and developmental toxicity; Effects in feeding study with Rhesus monkeys at 0.3-3.0 ppm include chloracne, sebaceous gland atrophy, involution of the thymus, and hyperplasia of gastric mucosa; [HSDB] See "Chlorodiphenyl (42% chlorine)." For IARC changes in 2016, see "Polychlorinated biphenyls" and the linked occupational disease.

Restricted

PCB's not commercially produced in the US since 1977; [HSDB]

Exposure Assessment
Vapor Pressure

1.64E-5 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Polychlorinated biphenyls."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Dermatotoxin

Chloracne

IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: