Agent Name

3,4-Dichloroaniline

CAS Number

95-76-1

Formula

C6-H5-Cl2-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-3,4-dichlorobenzene; 3,4-DCA; 3,4-Dichloranilin; 3,4-Dichloraniline; 3,4-Dichlorobenzenamine; 3,4-Dichlorophenylamine; 4,5-Dichloroaniline; 4-Amino-1,2-dichlorobenzene; Aniline, 3,4-dichloro-; Benzenamine, 3,4-dichloro-; DCA; DCA (VAN); LY 004892; m.p-Dichloroaniline; [ChemIDplus] UN1590; UN3442

Category

Amines, Aromatic

Description

Light-brown solid; [ICSC] Darkens on exposure to light and air; [CHEMINFO] Light brown crystalline solid; [MSDSonline]

Sources/Uses

Used to make dyes and pesticides; [Hawley]

Comments

An eye irritant; Can induce methemoglobinemia; May cause skin sensitization; [ICSC] High exposures can cause liver and kidney injury; May be toxic after skin absorption; [CAMEO] Toxic by inhalation, ingestion, and skin absorption; May cause serious damage to eyes; [eChemPortal: ESIS] No liver injury detected in study of workers exposed to 3,4-dichloroaniline in the production of diuron; Oral LD50 (rats) = 648 mg/kg; Dermal LD50 (cats) = 700 mg/kg; [HSDB] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; May cause skin sensitization; Can be absorbed through skin; Effects in high-dose animal studies include convulsions, cyanosis, lacrimation, and methemoglobinemia; [MSDSonline] Danger of cutaneous absorption; Danger of skin sensitization; [MAK]

Exposure Assessment
Vapor Pressure

0.00632 mm Hg

Lethal Concentration

LCLo (rat) = 65 mg/m3/4h

Explanatory Notes

Flash point = 166 deg C; [ICSC] The Guide in the Emergency Response Guidebook is for "Dichloroanilines, solid."

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: