Agent Name

3,4-Dichloronitrobenzene

CAS Number

99-54-7

Formula

C6-H3-Cl2-N-O2

Major Category

Nitrogen Compounds

Synonyms

1,2-Dichloro-4-nitrobenzene; 1-Nitro-3,4-dichlorobenzene; 3,4-Dichlornitrobenzen [Czech]; 3,4-Dichloronitrobenzen [Czech]; AI3-03268 (USDA); Benzene, 1,2-dichloro-4-nitro-; DCNB; [ChemIDplus] UN1578

Category

Nitros, Aromatic

Description

Colorless to tan solid; [ICSC] Fine yellow crystals; [MSDSonline]

Sources/Uses

Used to make herbicides, insecticides, and dyes; [HSDB]

Comments

A skin and eye irritant; May cause effects on the blood; [ICSC] May cause liver damage; [CAMEO] Causes methemoglobinemia in high-dose animals experiments; Methemoglobinemia also reported in exposed workers; Dermal LD50 (rats) >2000 mg/kg; Oral LDLo (rabbits) = 950 mg/kg; [HSDB] An eye irritant; Can be absorbed through skin; May cause skin sensitization; May induce methemoglobinemia; Effects in high-dose animal studies include cyanosis; [MSDSonline] No evidence of skin sensitization; [INCHEM: SIDS] Danger of cutaneous absorption; Could be carcinogenic for man but not conclusive because of insufficient data; [MAK]

Exposure Assessment
WEEL

1 ppm

Vapor Pressure

0.01 mm Hg

Lethal Concentration

LC50 (rat) = 10,000 mg/m3/4h

Explanatory Notes

Flash point = 124 deg C; [ICSC] The Guide in the Emergency Response Guidebook is for "Chloronitrobenzenes, solid."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

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