Agent Name

n-Butyl acetate

Alternative Name

Butyl acetate

CAS Number

123-86-4

Formula

C6-H12-O2

Major Category

Solvents

Synonyms

1-Butyl acetate; Acetate de butyle [French]; Acetic acid n-butyl ester; Acetic acid, butyl ester; Butile (acetati di) [Italian]; Butyl acetate; Butyl ethanoate; Butylacetat [German]; Butylacetaten [Dutch]; Butyle (acetate de) [French]; Butylester kyseliny octove [Czech]; Octan n-butylu [Polish]; n-Butyl acetate; n-Butyl acetate (natural); n-Butyl ethanoate; [ChemIDplus] UN1123

Category

Esters (<C12)

Description

Colorless liquid with a fruity odor; [NIOSH]

Sources/Uses

Used in solvent mixtures and to produce nitrocellulose lacquers, photographic film, nail polish removers, perfumes, oils, fats, vinyl resins, and camphor; Also used in food preservatives, inks, and printing processes; Occurs naturally in bananas; [ACGIH] In semiconductor manufacturing, n-butyl acetate is used to "develop" the pattern in the photoresists; [CHS, p. 44]

Comments

Narcosis induced in acute animal studies; In animal experiments, causes liver injury in doses greater than 500 mg/kg; [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC]

Reference Link

NIOSH Occupational Health Guidelines for Chemical Hazards: n-Butyl acetate

Exposure Assessment
Skin Designation (ACGIH)

No

TLV (ACGIH)

50 ppm

STEL (ACGIH)

150 ppm

PEL (OSHA)

150 ppm

MAK

100 ppm

IDLH (NIOSH)

1700 ppm

Excerpts from Documentation for IDLHs

Other animal data: A 4hour exposure to 10,000 ppm was not lethal to rats [Smyth 1956]. Human data: Severe irritation of the throat has been reported in volunteers exposed to 300 ppm for 3 to 5 minutes [Nelson et al. 1943]. However, it has also been reported that irritation of the eyes and nose is first objectionable at 3,300 ppm and that higher concentrations cause tearing and hyperemia of the conjunctiva [Grant 1974].

Vapor Pressure

11.5 mm Hg

Odor Threshold Low

0.06 ppm

Odor Threshold High

7.4 ppm

Lethal Concentration

LC50 (rat) = 390 ppm/4H

Explanatory Notes

IDLH = 10% LEL (lower explosive limit); Detection odor threshold from AIHA (mean = 0.31 ppm); Flash point = 22 deg C;

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: