Agent Name

alpha-Chlorohydrin

Alternative Name

Glycerol alpha-monochlorohydrin

CAS Number

96-24-2

Formula

C3-H7-Cl-O2

Major Category

Other Classes

Synonyms

Glycerol alpha-monochlorohydrin; 1,2-Dihydroxy-3-chloropropane; 1,2-Propanediol, 3-chloro-; 1-Chloro-1-deoxyglycerol; 1-Chloro-2,3-dihydroxypropane; 1-Chloropropane-2,3-diol; 2,3-Dihydroxypropyl chloride; 3-Chloro-1,2-dihydroxypropane; 3-Chloro-1,2-propanediol; 3-Chloro-1,2-propylene glycol; 3-Chloropropane-1,2-diol; 3-Chloropropanediol; 3-Chloropropylene glycol; Chlorhydrin; Chlorodeoxyglycerol; Chloropropanediol; Epibloc; Glycerin alpha-monochlorhydrin; Glycerin epichlorohydrin; Glycerol 3-chlorohydrin; Glycerol chlorohydrin; Glyceryl alpha-chlorohydrin; Glyceryl chloride; Glyceryl-alpha-chlorohydrin; Monochlorhydrin; Monochlorohydrin; U 5897; U-5897; alpha-Chlorohydrine; beta,beta'-Dihydroxyisopropyl chloride; [ChemIDplus] UN2689

Category

Halogenated Alcohols

Description

Colorless, hygroscopic liquid; [Hawley] Tends to turn straw-colored; [Merck Index] Colorless viscous liquid; [MSDSonline]

Sources/Uses

Used as a rodent chemosterilant, solvent (cellulose acetate, glyceryl phthalate resins, and gums), antifreeze agent for dynamite, and chemical intermediate for dyes and other organic chemicals; [HSDB] Found as a contaminant of acid-hydrolyzed vegetable proteins and soy sauce; [WHO]

Comments

Commercial product is mixture of the alpha and beta isomer; [Hawley] Numerous and severe adverse effects to male reproductive organs and sperm (including infertility) have been observed in rats and other mammals; [HSDB] May cause skin, eye, and mucous membrane irritation; Toxic by inhalation, ingestion, and skin contact; [CAMEO] Causes decreased sperm motility and count in rats at low doses, and testicular pathology at higher doses; [Reference #1] Reversible effect on male fertility by interfering with sperm function; No available information on pregnancy, lactation, or other effects to the female reproductive system; [REPROTOX] Well documented adverse effects to rat male reproductive system and sperm; Observations in intraperitoneal injection studies with rats and mice include lesions of the CNS (especially brain stem); Numerous studies indicate the kidney as the primary target organ for toxicity, with clear evidence of nephrotoxicity in a two year feeding study with rats; May be mutagenic in vitro at very high doses; Non mutagenic in vivo; Caused increase in benign tumor frequency in one study at dose higher than associated with renal tubule hyperplasia; [WHO]

Restricted

Restricted use pesticide in the US; One product registered for use indoors in industrial and commercial structures and in sanitary sewers for control of Norway rats; Not registered for outdoor use or for other rodent species; [Reference #1]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
MAK

0.005 ppm

Vapor Pressure

0.2 mm Hg

Lethal Concentration

LCLo (rat) = 125 ppm/4h

Explanatory Notes

Flash point = 145 deg C; [eChemPortal: IUCLID] VP = 3.75 mm Hg; [CAMEO]

Reference Link

IARC 2012: 3-Monochloro-1,2-Propanediol

Adverse Effects
Nephrotoxin

Yes

Reproductive Toxin

Yes

IARC Carcinogen

Possible Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: