Agent Name

3-Chloro-p-toluidine

CAS Number

95-74-9

Formula

C7-H8-Cl-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-3-chloro-4-methylbenzene; 2-Chloro-4-aminotoluene; 3-Chloro-4-methylaniline; 3-Chloro-4-methylbenzenamine; 3-Chloro-4-methylphenylamine; 4-Amino-2-chlorotoluene; 4-Methyl-3-chloroaniline; DRC 1339; DRC 1347; Benzenamine, 3-chloro-4-methyl-; p-Toluidine, 3-chloro-; [ChemIDplus] UN2239

Category

Amines, Aromatic

Description

Brown solid; [CAMEO] Low melting solid; mp = 22-25 deg C; [MSDSonline]

Sources/Uses

Used as a bird control agent and in the production of the acid dye palatine fast yellow; [HSDB]

Comments

A mutagen; Causes weakness and cyanosis in lethal-dose studies of rats; [RTECS] Negative evidence of carcinogenicity in studies of rats and mice; [NTP] Emergency treatment: methemoglobinemia; Toluidine compounds (both o- and p-) may cause methemoglobinemia and hemorrhagic cystitis, but the chlorinated derivatives are more potent in producing these effects; [HSDB] Skin sensitizer from human and guinea pig testing; [Reference #2] An irritant; Effects in high-dose animal studies include cyanosis; [MSDSonline]

Exposure Assessment
Vapor Pressure

0.04 mm Hg

Explanatory Notes

Flash point = 136 deg C; [eChemPortal: IUCLID] The Guide in the Emergency Response Guidebook is for "Chlorotoluidines, solid."

Adverse Effects
Skin Sensitizer

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

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Chemical Information

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Diseases

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Processes

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