Agent Name

3-Methyl-1-phenyl-2-pyrazolin-5-one

Alternative Name

Norphenazone

CAS Number

89-25-8

Formula

C10-H10-N2-O

Major Category

Nitrogen Compounds

Synonyms

Norphenazone; Phenyl methyl pyrazolone; 1-Fenyl-3-methyl-2-pyrazolin-5-on [Czech]; 1-Phenyl-3-methyl-5-oxo-2-pyrazoline; 1-Phenyl-3-methylpyrazolone; 1-Phenyl-3-methylpyrazolone-5; 2-Pyrazolin-5-one, 3-methyl-1-phenyl-; 3-Methyl-1-phenyl-5-pyrazolone; 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-; 5-Pyrazolone, 3-methyl-1-phenyl-; C.I. Developer 1; CI Developer 1; Developer Z; Edaravone; MCI-186; Methylphenylpyrazolone; Norantipyrine; Norphenazone; Phenylmethylpyrazolone; Radicut; [ChemIDplus]

Category

Pyrazoles

Description

White solid; [Merck Index] Light yellow odorless powder; [Alfa Aesar MSDS]

Sources/Uses

Used as an intermediate for dyes and drugs, reagent to detect cyanide, and developer for diazotized direct dyes; [HSDB] Used in the treatment of strokes; [Merck Index] Used for synthesis in the chemical industry and in the textile processing industry; [IUCLID] Used in hair dyes; [ExPub: EC]

Comments

Emergency treatment: Irritants; [HSDB] A skin, eye, and mucous membrane irritant; [CAMEO] Causes no to mild skin and eye irritation in rabbits; Not sensitizing to guinea pig skin; [IUCLID] No teratogenicity observed in experimental animals, but reduced birth weight and fetal loss seen at high doses; [REPROTOX] No evidence for carcinogenicity in mice or rats; [NTP] A mild eye irritant; Causes changes in liver and spleen in intravenous studies of dogs; [RTECS]

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