Agent Name

4-Chloroaniline

CAS Number

106-47-8

Formula

C6-H6-Cl-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-4-chlorobenzene; 4-Amino-1-chlorobenzene; 4-Aminochlorobenzene; 4-Chloranilin [Czech]; 4-Chloro-1-aminobenzene; 4-Chlorobenzamine; 4-Chlorobenzenamine; 4-Chlorophenylamine; Aniline, 4-chloro-; Aniline, p-chloro-; Benzenamine, 4-chloro-; Benzeneamine, 4-chloro; p-Aminochlorobenzene; p-CA; p-Chloraniline; p-Chloroaniline; p-Chlorophenylamine; [ChemIDplus] UN2018

Category

Amines, Aromatic

Description

Colorless, white, or pale-yellow solid with a characteristic sweet odor; [HSDB] Light tan chips or crystalline solid; [MSDSonline]

Sources/Uses

Used as a chemical intermediate for dyes, pharmaceuticals, agricultural chemicals, and urea herbicides; [HSDB]

Comments

An eye irritant; Inhalation of high concentrations can cause methemoglobinemia; [ICSC] Toxic by ingestion, inhalation, or skin absorption; [CAMEO] May be a skin sensitizer based on animal studies; [CHEMINFO] May cause skin sensitization; [eChemPortal: ESIS] In the past, cases of severe methemoglobinemia were reported in workers manufacturing this chemical; Evidence of liver and kidney injury in high-dose animal experiments; 3-15% methemoglobin levels induced in rats at a dose of 13-40 mg/kg; [HSDB] An irritant; May cause skin sensitization; Effects in high-dose animal studies include convulsions, methemoglobinemia, and cyanosis; [MSDSonline] Danger of cutaneous absorption; Danger of skin sensitization; [MAK]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Vapor Pressure

0.02 mm Hg

Lethal Concentration

LC50 (rat) = 2,340 mg/m3/4h

Explanatory Notes

Flash point = 120-123 deg C; [ICSC] The Guide in the Emergency Response Guidebook is for "Chloroanilines, solid."

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Primary

IARC Carcinogen

Possible Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: