Agent Name

4-Chlorophenol

CAS Number

106-48-9

Formula

C6-H5-Cl-O

Major Category

Other Classes

Synonyms

4-Chloro-1-hydroxybenzene; 4-Hydroxychlorobenzene; 4-Monochlorophenol; Applied 3-78; P-Chlorophenol; Parachlorophenol; Phenol, 4-chloro-; Phenol, p-chloro-; p-Chlorfenol [Czech]; p-Chlorophenic acid; p-Chlorophenol; [ChemIDplus] UN2020

Category

Chlorophenols

Description

White solid; Yellow or pink if not pure; Unpleasant, penetrating odor; [Hawley] Off-white crystalline powder; [MSDSonline]

Sources/Uses

Used as a chemical intermediate for pesticides, dyestuffs, and pharmaceuticals; Also used as a denaturant for alcohol, selective solvent in refining mineral oils, antiseptic, soil sterilant, adhesion promoting agent, and local antibacterial agent in root canal therapy; [HSDB]

Comments

A strong skin, eye, and respiratory tract irritant; May cause CNS effects; [ICSC] Causes burns to eyes and skin; Adverse effects are similar to those of phenol; [HSDB] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; May be absorbed through skin; Effects in high-dose animal studies include convulsions; [MSDSonline] See "Phenol." See "CHLOROPHENOLS."

Exposure Assessment
Vapor Pressure

0.08 mm Hg

Odor Threshold Low

1.2 ppm

Lethal Concentration

LC50 (rat) = 1,010 mg/m3/4H

Explanatory Notes

Flash point = 121 deg C; [Hawley] Odor threshold (recognition) from CHEMINFO; The Guide in the Emergency Response Guidebook is for "Chlorophenols, solid."

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: