Agent Name

p-tert-Butyltoluene

CAS Number

98-51-1

Formula

C11-H16

Major Category

Solvents

Synonyms

1-Methyl-4-tert-butylbenzene; 1-tert-Butyl-4-methylbenzene; 4-Methyl-tert-butylbenzene; 4-tert-Butyl-1-methylbenzene; 4-tert-Butyltoluene; 8-Methylparacymene; Benzene, 1-(1,1-dimethylethyl)-4-methyl-; PTBT; TBT; Toluene, p-tert-butyl-; p-Methyl-tert-butylbenzene; p-TBT; p-t-Butyltoluene; p-tert-Butyltoluene; [ChemIDplus] UN2667

Category

Aromatic Solvents

Description

Colorless liquid with a distinct aromatic odor; somewhat like gasoline; [NIOSH]

Sources/Uses

Used as solvent for resins and as a chemical intermediate for the chemical and pharmaceutical industries; [HSDB]

Comments

Liver injury occurs in chronic inhalation studies of experimental animals. Giddiness was observed in volunteers exposed at 160 ppm. [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

1 ppm

PEL (OSHA)

10 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the female rat 1hour LC50 of 934 ppm reported by Hine et al. [1954]. . . . Human data: Giddiness and altered respiration have been reported in volunteers exposed to 160 ppm for 15 minutes [Hine et al. 1954].

Vapor Pressure

0.67 mm Hg

Odor Threshold Low

5 ppm

RD50

360 ppm

Lethal Concentration

LC50 (rat) = 165 ppm/8H

Explanatory Notes

Odor threshold (recognition) from CHEMINFO; Flash point = 136 deg F;

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: