Disease/Syndrome

Neuropathy, toxic

Category

Chronic Poisoning

Acute/Chronic

Chronic

Synonyms

Toxic polyneuropathy; Peripheral neuropathy induced by occupational toxin;

Comments

Most symmetrical, sensorimotor neuropathies caused by exposure to chemicals are indistinguishable from similar effects caused by systemic diseases such as alcoholism, diabetes mellitus, uremia, or B12 deficiency. The diagnosis of toxic polyneuropathy is usually made on the basis of symptoms following exposure to the chemical and the resolution of symptoms months to years after cessation of exposure. [LaDou, p. 428] Chemicals that Can Cause Toxic Polyneuropathy: C: Carbon disulfide; L: Lead; A: Arsenic, Acrylamide; M: Mercury; N: N-hexane; O: Organophosphates (Ops); T: Thallium; E: Ethylene oxide; Some Ops can Induce Delayed Neuropathy (OPIDN). OPIDN usually occurs after ingestion, and is usually nonoccupational. [Levy, p. 431] Lead, n-hexane, and Ops tend to cause predominantly motor neuropathy, while the other agents produce sensorimotor neuropathy. [Rom, p. 640-55]

Latency/Incubation

Weeks to months

Diagnostic

History; Neurological examination; EMG and nerve conduction test

ICD-9 Code

357.7

Related Information in Haz-Map
Symptoms/Findings

Symptoms/Findings associated with this disease:

Job Tasks

High risk job tasks associated with this disease:

Agents

Hazardous agents that cause the occupational disease: