Agent Name

5-Amino-o-cresol

CAS Number

2835-95-2

Formula

C7-H9-N-O

Major Category

Nitrogen Compounds

Synonyms

4-Amino-2-hydroxy-1-methylbenzene; Phenol, 5-amino-2-methyl-; 2-Hydroxy-p-toluidine; 3-Amino-6-methylphenol; 3-Hydroxy-4-methylaniline; 4-Amino-2-hydroxytoluene; 5-Amino-2-methylphenol; 6-Methyl-3-aminophenol; [ChemIDplus]

Category

Amino Phenols

Description

Brown solid; [CAMEO] Slightly beige powder; [MSDSonline]

Sources/Uses

Used as a coupler in oxidative hair dyeing; [HSDB]

Comments

A mutagen; Causes somnolence and ataxia in lethal-dose feeding studies of rats; [RTECS] Induces goiter, hypothyroidism, and liver injury in feeding studies of rats for 13 weeks; No difference in chromosomal aberrations between controls and subjects who dyed their hair with 2-hydroxy-4-aminotoluene 13 times at intervals of 3-6 weeks; Very weak skin sensitizer in guinea pigs; Did not induce photosensensitization in guinea pigs; [HSDB] A skin, eye, and mucous membrane irritant; [CAMEO] An irritant; [MSDSonline]

Exposure Assessment
Vapor Pressure

0.00026 mm Hg

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: