Agent Name

5-Chloro-o-toluidine

CAS Number

95-79-4

Formula

C7-H8-Cl-N

Major Category

Nitrogen Compounds

Synonyms

5-Chloroaminotoluene; 1-Amino-3-chloro-6-methylbenzene; 2-Amino-4-chlorotoluene; 2-Methyl-5-chloroaniline; 3-Chloro-6-methylaniline; 4-Chloro-2-aminotoluene; 5-Chloro-2-methylaniline; 5-Chloro-2-methylbenzenamine; 5-Chloro-2-toluidine; Acco Fast Red KB Base; Ansibase Red KB; Azoene Fast Red KB Base; Azoic Diazo Component 32; C.I. Azoic Diazo Component 32; Fast Red KB Salt; Fast Red KB Salt Supra; Fast Red KB amine; Fast Red KB base; Fast Red KB-T Base; Fast Red KBS Salt; Genazo Red KB Soln; Hiltonil Fast Red KB Base; Lake Red BK Base; Lake Red KB Base; Metrogen Red Former KB Soln; Naphthosol Fast Red KB Base; Pharmazoid Red KB; Red KB Base; Spectrolene Red KB; Stable Red KB Base; o-Toluidine, 5-chloro-; Benzenamine, 5-chloro-2-methyl-; [ChemIDplus] UN2239

Category

Amines, Aromatic

Description

Grayish-white solid; [HSDB] Low melting solid; mp = 20-22 deg C; [MSDSonline]

Sources/Uses

Used in the synthesis of organic dyestuffs; [HSDB]

Comments

Hemorrhagic cystitis and methemoglobinemia were reported in workers handling this chemical to manufacture dyes. Skin absorption was the most likely route of exposure; Causes liver cancer in high-dose feeding studies in experimental animals; [HSDB] An irritant; May induce methemoglobinemia; [MSDSonline]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Vapor Pressure

0.04 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Chlorotoluidines, solid."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Primary

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: