Agent Name

5-Methoxypsoralen

CAS Number

484-20-8

Formula

C12-H8-O4

Major Category

Other Classes

Synonyms

4-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one; 5-Methoxy psoralen; 5-Methoxy-6,7-furanocoumarin; 5-MOP; 6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone; 7H-Furo(3,2-g)(1)benzopyran-7-one, 4-methoxy-; Bergaptan; Bergapten; Bergaptene; Heraclin; Majudin; Psoraderm; [ChemIDplus]

Category

Other Organic Compounds

Description

Grayish-white or yellow solid; [CAMEO] White powder; [MSDSonline]

Sources/Uses

Used to promote tanning in suntan preparations and to treat psoriasis; Present in some perfumes, fragrances, sunscreen preparations, and food products (as a component of bergamot oil); [HSDB]

Comments

A phototoxic agent; Emergency treatment: "Psoralens"; Combining psoralens and UV light is called PUVA therapy; Therapeutic doses are 0.6 mg/kg; Toxic hepatitis has been reported after PUVA therapy; [HSDB] An irritant; Effects in high-dose animal studies include, convulsions, photosensitivity (after systemic exposure), and hepatitis; May cause cancer; May cause heritable genetic damage; [MSDSonline]

Reference Link

Photosensitivity from harvesting lovage (Levisticu... [Contact Dermatitis. 1992] - PubMed result

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Dermatotoxin

Contact Dermatitis, Photoirritant

IARC Carcinogen

Probable Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: