Agent Name

8-Methoxypsoralen

Alternative Name

Methoxsalen

CAS Number

298-81-7

Formula

C12-H8-O4

Major Category

Other Classes

Synonyms

Methoxsalen; 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone; 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone; 7H-Furo(3,2-g)(1)benzopyran-7-one, 9-methoxy-; 8-MOP; 8-Methoxy-(furano-3'.2':6.7-coumarin); 8-Methoxy-2',3',6,7-furocoumarin; 8-Methoxy-4',5',6,7-furocoumarin; 8-Methoxypsoralene; 9-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one; 9-Methoxypsoralen; Ammodin; Ammoidin; Geroxalen; Meladinin; Meladinin (VAN); Meladinine; Meladoxen; Meloxine; Methoxa-Dome; New-Meladinin; Oxsoralen; Oxsoralen Lotion; Oxsoralen Ultra; Oxsoralen-Ultra; Oxypsoralen; Psoralon-MOP; Puvalen; Puvamet; Uvadex; Xanthotoxin; Xanthotoxine; [ChemIDplus]

Category

Other Organic Compounds

Description

White to cream-colored solid; [Hawley] Sensitive to light and air; [CAMEO] Light yellow crystalline powder; [MSDSonline]

Sources/Uses

Used to enhance pigmentation and to repigment vitiliginous areas; [HSDB] Used either systemically or topically in combination with ultraviolet light; [REPROTOX]

Comments

A phototoxic agent; Emergency treatment: "Psoralens"; Combining psoralens and UV light is called PUVA therapy; Therapeutic doses are 0.6 mg/kg; Toxic hepatitis has been reported after PUVA therapy; [HSDB] Embryotoxic in high-dose animal studies, but no evidence of increased risk in humans; [REPROTOX] An irritant; Effects in high-dose animal studies include, convulsions, photosensitivity (after systemic exposure), and hepatitis; May cause cancer; May cause heritable genetic damage; [MSDSonline]

Exposure Assessment
Explanatory Notes

8-methoxypsoralen plus ultra-violet radiation is a known human carcinogen; [IARC]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Dermatotoxin

Contact Dermatitis, Photoirritant

IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: