Agent Name

Acetamide

CAS Number

60-35-5

Formula

C2-H5-N-O

Major Category

Nitrogen Compounds

Synonyms

Acetic acid amide; Acetimidic acid; Acetimidic acid (VAN); Amid kyseliny octove [Czech]; Ethanamide; Methanecarboxamide; [ChemIDplus]

Category

Other Nitrogen Compounds

Description

Colorless, deliquescent solid; [Hawley] Colorless crystals; [MSDSonline]

Sources/Uses

Used as a solvent, plasticizer, stabilizer, humectant for paper, hygroscopic agent, wetting agent, penetrating agent, and denaturant of alcohol; Also used in lacquers, explosives, and soldering fluxes; [HSDB] Used as a solvent in the following applications: plasticizers, lacquers, explosives, soldering flux, wetting agents, and synthesis of other agents; [ACGIH]

Comments

"There are no human data, but long-term feeding studies in rats using high doses of acetamide (up to 5% in diet) produced liver damage and hepatocellular carcinomas. . . . high doses producing maternal toxicity may cause developmental toxicity." The acute toxicity after ingestion is relatively low: an LD50 of 1000-7000 mg/kg in rats and mice; [ACGIH] A skin and eye irritant; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

1 ppm, inhalable fraction and vapor

Vapor Pressure

0.04 mm Hg

Lethal Concentration

LC50 (rat) = 16,000 ppm

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: