Agent Name

Ethylene dibromide

Alternative Name

1,2-Dibromoethane

CAS Number

106-93-4

Formula

C2-H4-Br2

Major Category

Pesticides

Synonyms

Ethylene bromide; Glycol dibromide; 1,2-Dibromoethane; [NIOSH]

Category

Fumigants

Description

Colorless liquid or solid (below 50 degrees F) with a sweet odor. [fumigant] [NIOSH]

Sources/Uses

Used as a fumigant, a solvent, a scavenger for lead in leaded gasoline, and an intermediate in organic synthesis; no longer used in the United States as a soil or grain fumigant; [ACGIH]

Comments

In acute exposure studies in animals, ethylene dibromide is more toxic than a comparable dose of ethylene dichloride or carbon tetrachloride. It causes narcosis, respiratory irritation, kidney damage, and liver injury. [ACGIH] Strong positive data that ethylene dibromide can cause testicular damage in humans; [Frazier, p. 194]

Restricted

Use as fumigant suspended by EPA due to toxicity and ground water contamination. [Sullivan, p. 1053]

Reference Link

EXTOXNET - Ethylene Dibromide

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

PEL (OSHA)

20 ppm, Ceiling(OSHA) = 30 ppm (50 ppm for 5-min peak per 8-hour shift)

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

Exposures above 100 ppm for an hour or less or by longer exposures at lower concentrations (e.g., 75 ppm) have resulted in gastrointestinal discomfort, vomiting, and respiratory involvement [Ott et al. 1980].

Vapor Pressure

12 mm Hg

Lethal Concentration

LC50 (rat) = 1,831 ppm/30 min

Explanatory Notes

Carcinogen--No TLV;

Half Life

Whole body (animal studies): less than 72 hours; [TDR, p. 640]

Reference Link

ATSDR Medical Management - Ethylene dibromide

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Primary

Nephrotoxin

Yes

Reproductive Toxin

Yes

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: