Agent Name

Captafol

Alternative Name

Difolatan

CAS Number

2425-06-1

Formula

C10-H9-Cl4-N-O2-S

Major Category

Pesticides

Synonyms

Captofol; N-((1,1,2,2-Tetrachloroethyl)thio)-4-cyclohexene-1,2-dicarboximde; Crisfolatan; Difosan; Folcid; Haipen; Kenofol; Merpafol; Pillartan; Sanseal; Santar-SM; Sanspor; Difolatan

Category

Fungicides

Description

White, crystalline solid with a slight, characteristic pungent odor. [fungicide] [Note: Available commercially as a wettable powder or in liquid form.] [NIOSH]

Sources/Uses

The thiophthalimides are widely used fungicides on seeds, field crops, and stored produce; [EPA Pesticides] Used as an agricultural fungicide in large quantities worldwide; Limited industrial use in paints and plastics; [ACGIH]

Comments

The thiophthalimides include captan, captafol, and folpet; no systemic poisonings in humans have been reported; [EPA Pesticides] Allergic contact dermatitis in pesticide handlers is most likely due to maneb, carbofuran, carbaryl, captan, folpet, or captafol. [Marks, p. 312] TLV Basis is liver damage, kidney damage and dermal sensitization; A potential respiratory sensitizer; [ACGIH]

Restricted

Captafol is no longer registered in the U.S. [EPA Pesticides]

Reference Link

Occupational asthma in a pesticides manufacturing worker

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.1 mg/m3, inhalable fraction and vapor

Vapor Pressure

8.0E-6 mm Hg

Reference Link

ICSC: Captafol

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: