Agent Name

Acetoacetanilide

CAS Number

102-01-2

Formula

C10-H11-N-O2

Major Category

Nitrogen Compounds

Synonyms

((Acetoacetyl)amino)benzene; 1-(Phenylcarbamoyl)-2-propanone; 3-Oxo-N-phenylbutanamide; Acetanilide, 2-acetyl-; Acetoacetamidobenzene; Acetoacetanilid; Acetoacetanilide; Acetoacetic acid anilide; Acetoacetic anilide; Acetoacetylaniline; Anilid kyseliny acetoctove; Anilid kyseliny acetoctove [Czech]; Butanamide, 3-oxo-N-phenyl-; Butanoic acid, 3-oxo-, amide, N-phenyl-; N-(Acetylacetyl)aniline; N-Phenylacetoacetamide; alpha-Acetyl-N-phenylacetamide; beta-Ketobutyranilide; [ChemIDplus] AAA; [Reference #1]

Category

Other Aromatics (Nitrogen)

Description

White solid; [Hawley] White, odorless crystalline powder; [Alfa Aesar MSDS]

Sources/Uses

Used in rubber compounding and in manufacturing other chemicals (hansa yellow dyes, benzidine yellow pigments, the fungicides carboxin and methfuroxam, and pyrazolones and pyrimidines); [HSDB]

Comments

Reports of reversible eye burns in humans; Not irritating to skin and mildly irritating to eyes of rabbits; No evidence of skin sensitization in guinea pigs; Causes slight methemoglobinemia and significant formation of Heinz bodies in cats following single oral administration of 100 mg/kg; Hemolytic anemia and corresponding injury to liver, spleen, and kidneys observed in 28-day oral study of rats (850 mg/kg/day and, to some extent, at 100 mg/kg/day); Emergency treatment: "Phenacetin"; Phenacetin was used as a pain-relieving drug, but has not been available in the US since 1983. Can cause methemoglobinemia after ingestion >1 gram/day; Can cause renal papillary necrosis following ingestion of large doses for years; [HSDB] A weak allergen; [CAMEO] A mild skin irritant; Can be absorbed through skin; [Alfa Aesar MSDS]

Reference Link

OECD SIDS: Acetoacetanilide - 1998

Exposure Assessment
Vapor Pressure

0.01 mm Hg

Explanatory Notes

Flash point = 162.7 deg C; [Hawley]

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

No other related information on this agent was found.