Agent Name

Acetyl tributyl citrate

CAS Number

77-90-7

Formula

C20-H34-O8

Major Category

Other Classes

Synonyms

1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester; 2-(Acetyloxy)-1,2,3-propanetricarboxylic acid, tributyl ester; 2-Acetyltributylcitrate; 2-Acetoxy-1,2,3-propanetricarboxylic acid tributyl ester; Acetyl tributyl citrate; Acetylcitric acid, tributyl ester; Blo-trol; Citric acid, tributyl ester, acetate; Citroflex A; Citroflex A 4; Tributyl 2-(acetyloxy)-1,2,3-propanetricarboxylate; Tributyl 2-acetoxy-1,2,3-propanetricarboxylate; Tributyl O-acetylcitrate; Tributyl acetyl citrate; Tributyl acetylcitrate; Tributyl citrate acetate; [ChemIDplus]

Category

Esters, Other

Description

Colorless liquid with a mild sweet odor; [HSDB]

Sources/Uses

Used as a flavoring agent and plasticizer for vinyl resins, rubber, and cellulosic resins; Also used to make resinous and polymeric coatings and paper/paperboard for use in contact with food; [HSDB]

Comments

Emergency treatment: "Irritants"; No observations of skin irritation or sensitization in study with 59 volunteers; Intravenous dosing of cats and rabbits caused dose-related drop in blood pressure (found to be caused by cardiac inhibition); Other effects noted in high-dose animal studies by different exposure routes include decreased weight gain, decreased hemoglobin (no indication of aplastic anemia in bone marrow smears), and neurological effects (i.e. local anesthesia and blockage of neural transmission); No evidence of mutagenicity and limited evidence of cytotoxicity; [HSDB] Causes somnolence in lethal-dose feeding studies of rats; [RTECS] Safe to use as a flavoring agent in food; [JECFA]

Exposure Assessment
Vapor Pressure

4.55E-6 mm Hg

Explanatory Notes

Flash point = 204 deg C; [Hawley]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: