Agent Name

Carbonyl fluoride

CAS Number

353-50-4

Formula

C-F2-O

Major Category

Toxic Gases & Vapors

Synonyms

Carbon difluoride oxide; Carbon fluoride oxide (COF2); Carbon oxyfluoride (COF2); Carbonic difluoride; Carbonyl difluoride; Carbonyl fluoride; Carbonyl oxyfluoride; Difluoroformaldehyde; Difluorooxomethane; Fluophosgene; Fluoroformyl fluoride; Fluorophosgene; [ChemIDplus] UN2417

Category

Acid Halides

Description

Colorless gas with a pungent and very irritating odor; Note: Shipped as a liquefied compressed gas; [NIOSH]

Sources/Uses

Used in organic synthesis; generated from the thermal degradation of fluoropolymers, e.g., polytetrafluoroethylene (PTFE) and polyfluoroethylenepropylene; [ACGIH]

Comments

Liquid is a severe skin irritant; [CHRIS] Toxic effects from the liberation of fluoride by hydrolysis; causes pulmonary edema in animals exposed to lethal concentrations and liver and kidney damage in subchronic studies; "Critical Effects" are irritation; bone; fluorosis. [ACGIH] Possible frostbite from contact with liquid; [NIOSH] See "FLUORIDES."

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TIH

Yes

TLV (ACGIH)

2 ppm

STEL (ACGIH)

5 ppm

Lethal Concentration

LC50 (rat) = 360 ppm/1h

Reference Link

ICSC: Carbonyl fluoride

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: