Agent Name

p-Aminobenzoic acid

CAS Number

150-13-0

Formula

C7-H7-N-O2

Major Category

Other Uses

Synonyms

1-Amino-4-carboxybenzene; 4-Aminobenzoic acid; 4-Carboxyaniline; Acido p-aminobenzoico [Italian]; Acidum paraminobenzoicum; Amben; Anti-chromotrichia factor; Anticanitic vitamin; Bacterial vitamin H1; Benzoic acid, 4-amino; Benzoic acid, 4-amino-; Benzoic acid, p-amino-; Chromotrichia factor; Hachemina; Kyselina p-aminobenzoova [Czech]; PAB; PABA; Pabacyd; Pabafilm; Pabamine; Papacidum; Paraminol; Paranate; Potaba; RVPaba Lipstick; Romavit; Rvpaba; Sunbrella; Super Shade by Coppertone; Trichochromogenic factor; Vitamin BX; Vitamin H'; p-Carboxyaniline; p-Carboxyphenylamine; para-Aminobenzoic acid; [ChemIDplus]

Category

Sunscreens

Description

Light beige, odorless solid; pure form is white; discolor on exposure to light and air; [Hawley] White crystalline solid; [MSDSonline]

Sources/Uses

Used to make local anesthetics, folic acid, and azo dyes; Also used in feed additives, sunscreens, and medications; [HSDB] Occurs naturally as B complex factor--about 10-100 ppm in brewer's yeast;

Comments

Oral LD50 = 1000 mg/kg (dog), 1830 mg/kg (rabbit), and 6000 mg/kg (rat); Causes acute hepatic necrosis in dogs given 2-3 g/kg; [HSDB] May cause irritation; May induce methemoglobinemia; [MSDSonline] May cause allergic dermatitis when applied as a sunscreen; No skin sensitization reported in occupational setting; [AIHA] "Patients may be allergic or photoallergic to PABA. If photoallergic, they may not react to PABA alone, but only with sun exposure." [Marks, p. 212]

Exposure Assessment
WEEL

5 mg/m3

Vapor Pressure

0.000278 mm Hg

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Contact Dermatitis, Photoallergic

IARC Carcinogen

Not Classifiable

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Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: