Agent Name

Ethylene dichloride

Alternative Name

1,2-Dichloroethane

CAS Number

107-06-2

Formula

C2-H4-Cl2

Major Category

Solvents

Synonyms

Ethylene chloride; Glycol dichloride; 1,2-Dichloroethane; [NIOSH]

Category

Chlorinated Aliphatics

Description

Colorless liquid with a pleasant, chloroform-like odor. [Note: Decomposes slowly, becomes acidic & darkens in color.] [NIOSH]

Sources/Uses

Used in organic synthesis; used in the past as a solvent, degreaser, paint remover, and fumigant; [ACGIH] Has been used as a dry cleaning agent and solvent for degreasing, resins, adhesives, coasmetics, and pharmaceuticals; [HSDB]

Comments

Liquid causes first degree burns on short exposure; [CHRIS] Can cause nausea and vomiting, narcosis, liver and kidney injury, and death after high inhalation exposure; [ACGIH]

Restricted

Use as fumigant suspended by EPA due to toxicity. [Sullivan, p. 1053]

Reference Link

ATSDR - ToxFAQs - 1,2-Dichloroethane

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

10 ppm

PEL (OSHA)

50 ppm, Ceiling(OSHA) = 100 ppm (200 ppm for 5-min peak in any 3 hrs)

IDLH (NIOSH)

50 ppm

Excerpts from Documentation for IDLHs

The chosen IDLH is based on the maximum timeconcentration in air of 1,000 ppm which was survived by female rats for 1.5 hours.

Vapor Pressure

64 mm Hg

Odor Threshold Low

6 ppm

Odor Threshold High

111 ppm

Lethal Concentration

LC50 (rat) = 1,000 ppm/7 hr

Explanatory Notes

Detection odor threshold from AIHA (mean = 26 ppm);

Half Life

Whole body (animal studies): complete elimination within 48 hours; [TDR, p. 649]

Reference Link

ICSC: 1,2-Dichloroethane

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Primary

Nephrotoxin

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: