Agent Name

Chloroacetyl chloride

CAS Number

79-04-9

Formula

C2-H2-Cl2-O

Major Category

Toxic Gases & Vapors

Synonyms

Acetyl chloride, chloro-; Chloracetyl chloride; Chlorid kyseliny chloroctove [Czech]; Chloroacetic acid chloride; Chloroacetic chloride; Chlorure de chloracetyle [French]; Monochloroacetyl chloride; [ChemIDplus] UN1752

Category

Acid Halides

Description

Colorless to yellowish liquid with a strong, pungent odor; [NIOSH]

Sources/Uses

Used in organic synthesis; [ACGIH]

Comments

Liquid causes second or third degree burns after short contact; [CHRIS] Corrosive to skin; [Quick CPC] Hydrolysis of chloroacetyl chloride yields chloroacetic acid and hydrogen chloride gas. It causes "clinical and pathologic evidence of respiratory effects" at the lowest concentrations tested in experimental animals; [ACGIH] A lachrymator; [HSDB] A corrosive substance that can cause pulmonary edema; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

Dangerous When Wet

Yes - A material that, by contact with water, is liable to become spontaneously flammable or to give off flammable or toxic gas at a rate greater than 1 L per kilogram of the material, per hour; [ERG 2004]

TLV (ACGIH)

0.05 ppm

STEL (ACGIH)

0.15 ppm

IDLH (NIOSH)

1 ppm

Vapor Pressure

25.2 mm Hg

Lethal Concentration

LC50 (rat) = 660 ppm/1h

Explanatory Notes

Some Water Reactive Materials are also TIH materials themselves: Chloroacetyl chloride; [ERG 2016]

Reference Link

ICSC: Chloroacetyl chloride

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Diseases

Occupational diseases associated with exposure to this agent:

Processes

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