Agent Name

Epichlorohydrin

Alternative Name

1-Chloro-2,3-epoxypropane

CAS Number

106-89-8

Formula

C3-H5-Cl-O

Major Category

Plastics & Rubber

Synonyms

2-Chloropropylene oxide; gamma-Chloropropylene oxide; 1-Chloro-2,3-epoxypropane; [NIOSH] UN2023

Category

Epoxides

Description

Colorless liquid with a slightly irritating, chloroform-like odor; [NIOSH]

Sources/Uses

Used primarily in the manufacture of epoxy and phenoxy resins; [ACGIH]

Comments

Can cause severe skin burns and a skin sensitizer; Inhalation of vapor can cause lung edema and asthma-like reactions; [ICSC] In high-dose animal studies, epichlorohydrin causes testicular damage and sterility. [Frazier, p. 340] Animals exposed in subchronic inhalation studies at 50 ppm show kidney damage and liver effects. [ACGIH] Suspected germ cell mutagen (3B); [MAK] Destructive to mucous membranes and upper respiratory tract; [Sigma-Aldrich MSDS] Epichlorohydrin (UN2023) has warning of explosive polymerization; [ERG 2016]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.5 ppm

PEL (OSHA)

5 ppm

IDLH (NIOSH)

75 ppm

Excerpts from Documentation for IDLHs

Human data: Workers engaged in the production of epichlorohydrin from dichlorohydrin glycerin, with isolated exposures to epichlorohydrin ranging from 4.9 to 54.9 ppm, showed no apparent adverse effects [Pet'ko et al. 1966]. Concentrations of 20 ppm produced transient burning of the eyes and nasal mucosa, 40 ppm produced eye and throat irritation that persisted for 48 hours, and concentrations in excess of 100 ppm were considered intolerable with a potential for lung edema and kidney lesions [NIOSH 1976].

Vapor Pressure

16.4 mm Hg

Odor Threshold Low

0.08 ppm

Odor Threshold High

12 ppm

RD50

687 ppm

Lethal Concentration

LC50 (rat) = 250 ppm/8 hr

Explosive Polymerization

Yes

Explanatory Notes

Odor threshold from AIHA; Flash point = 88 deg F; [CHEMINFO]

Half Life

No reports found; [TDR, p. 619]

Reference Link

ICSC: Epichlorohydrin

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Reproductive Toxin

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: