Agent Name

alpha-Terpineol

CAS Number

98-55-5

Formula

C10-H18-O

Major Category

Biological Agents

Synonyms

1-Menthene-8-ol; 1-p-Menthen-8-ol; 2-(4-Methyl-3-cyclohexenyl)-2-propanol; 3-Cyclohexene-1-methanol, alpha,alpha,4-trimethyl-; PC 593; Terpenol; Terpineol 350; Terpineol schlechthin; alpha,alpha,4-Trimethyl-3-cyclohexene-1-methanol; alpha-Terpineol (natural); p-Menth-1-en-8-ol; [ChemIDplus]

Category

Wood Dusts & Extracts

Description

White solid with an odor of lilac; [HSDB] Some forms are liquid; [Merck Index] White low melting solid; mp = 31-32 deg C; [MSDSonline]

Sources/Uses

A major ingredient of pine oil disinfectants; Used as a fragrance in perfumes and soaps, fat denaturant for soap manufacturing, synthetic flavoring agent, organic solvent, antioxidant, and antiseptic; [HSDB]

Comments

Histopathological changes observed in lungs of horses surviving IV injection; Moderately irritating to rabbit skin; Skin sensitization reported in two patients, but no positive reactions in volunteers or guinea pigs; Terpineols: Eye and mucous membrane irritants and CNS depressants; Emergency treatment: "Pine oil"; [HSDB] Included in list of "established contact allergens in humans"; [ToxPlanet: EC: Scientific Committee on Consumer Safety: Fragrance allergens in cosmetic products (2011)] Severely irritating to skin of mice and mildly irritating to rabbit skin; Causes flaccid paralysis, somnolence, and ataxia in oral studies of rats at >2900 mg/kg; Changes to liver and dehydrogenase levels observed in intermittent 30-day feeding study of rats; [RTECS] Safe when used as a flavoring agent in food; [JECFA] No information available on reproduction or lactation effects; [REPROTOX]

Exposure Assessment
Vapor Pressure

0.04 mm Hg

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Diseases

Occupational diseases associated with exposure to this agent:

Processes

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