Disease/Syndrome

Melioidosis

Category

Infection, Occupational

Acute/Chronic

Chronic

Synonyms

Whitmore disease; Burkholderia pseudomallei infection;

Biomedical References

Search PubMed

Comments

INITIAL SYMPTOMS: Pneumonia (from mild to fulminant septic shock); Chronic lung infection (mimicking tuberculosis); Skin ulcers & abscesses; Suppurative parotitis in children in Thailand; [PPID] Acute to chronic & localized to disseminated infections; [Guerrant] EPIDEMIOLOGY: Infection occurs through contact with contaminated water or soil through breaks in the skin, inhalation, or ingestion. Rice farmers in Thailand are at risk for this disease. Some chronic diseases (diabetes, cirrhosis, alcoholism, renal failure, COPD, thalassemia, malignancy) increase the risk of contracting the disease. The mortality rate ranges from 15 to 40%. Horses are the primary reservoir; also sheep, goats, swine, monkeys and rodents; [CCDM, p. 397-400] Risk factors include diabetes, alcoholism, chronic renal disease, COPD, thalassemia, and malignancy. [CDC Travel, p. 260] FINDINGS These saprophytic bacteria may infect humans and other animals. About 50% of patients present with acute pneumonia. Some patients develop rapidly fatal septicemia. The disease may be confused with typhoid fever or tuberculosis. Findings may include pulmonary cavitation, empyema, chronic abscesses, and osteomyelitis. In 5% of cases in northern Australia, patients have meningoencephalitis with paralysis and weakness. [CCDM, p. 397-8] A petechial or purpuric rash may occur. Jaundice may occur in septicemic melioidosis. Leukopenia, lack of fever, azotemia, and abnormal liver function tests are poor prognostic indicators. Empyema and purulent pericarditis are complications. [Guerrant, p. 220, 956] The disease may present as sepsis and "overwhelming necrotizing pneumonia." Other findings may include pleuritic chest pain, normal or elevated WBC count, arthritis, meningitis, septic shock, abdominal pain, diarrhea, pharyngitis, skin pustules, lymphadenitis, cyanosis, myalgias, and abnormal liver function tests. Chest x-ray findings may include pleural effusions, nodular infiltrates, cavitation, and consolidation. [Merck Manual, p. 1254] Liver and spleen abscesses are common in patients with septicemic melioidosis. Unlike TB, hilar adenopathy is not usually found in pulmonary infections caused by B. pseudomallei. Acute suppurative parotitis caused by B. pseudomallei occurs in about 1/3 of pediatric cases of melioidosis in Thailand. [Guerrant, p. 220-1] Presentations of 363 cases in Northern Australia were pneumonia (81), genitourinary (21), skin abscesses (45), soft tissue abscesses (11), neurologic (12), and osteomyelitis/septic arthritis (5). Mortality was 5% in pneumonia cases and 25% in neurologic cases. Genitourinary diseases include prostate abscesses and orchitis. Neurologic diseases include encephalomyelitis, cranial nerve palsies, brain abscesses, motor weakness, and paralysis. 12% of patients presented with chronic symptoms similar to tuberculosis (fever, weight loss, and productive cough). [PPID, p. 2544-8] 1/4 of Thai patients have urinary symptoms including hematuria. [Cohen, p. 1214] Chronic pulmonary disease may mimic tuberculosis. Regional lymphadenopathy may accompany skin lesions. [Harrison ID, p. 564]

Latency/Incubation

1-21 days or as short as a few hours after high dose exposure; Latent foci may reactivate years after exposure; [CCDM, p. 399]

Diagnostic

Indirect hemagglutination assay (IHA) and ELISA assays are useful for ill tourist returning from endemic area, but culture is definitive test. [PPID]

ICD-9 Code

025

Effective Antimicrobics

Yes

Reference Link

CDC - Melioidosis

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