Agent Name

Arsenic trifluoride

CAS Number

7784-35-2

Formula

As-F3

Major Category

Metals

Synonyms

Arsenic fluoride; Arsenic fluoride (AsF3); Arsenous fluoride; Arsenous trifluoride; TL 156; Trifluoroarsine; [ChemIDplus] Arsenic (III) fluoride; [MSDSonline] UN1556

Category

Arsenic Compounds, Inorganic

Description

Liquid; Fumes in air; [Merck Index]

Sources/Uses

Used as a dopant and to make arsenic pentafluoride, hexaflouroarsonite compounds, and graphite intercalated compounds; Also used as a fluorinating agent and catalyst; [HSDB]

Comments

Extremely toxic; [Merck Index] A skin, eye, and respiratory tract irritant; [HSDB] An irritant; Toxic by ingestion or inhalation; [MSDSonline] Trivalent arsenic compounds (arsenic trioxide, trifluoride, and trichloride) are more toxic that the pentavalent compounds because the former are more water soluble. [Ullmann] See "Arsenic" and the linked occupational diseases.

Exposure Assessment
BEI

Inorganic arsenic plus methylated metabolites in urine = 35 ug As/L; end of workweek; Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift; (Repeated measurements recommended.)

TLV (ACGIH)

0.01 mg/m3, as As (2.5 mg/m3, as F)

PEL (OSHA)

0.01 mg/m3, as As (2.5 mg/m3, as F)

MAK

1 mg/m3, inhalable fraction, as F

IDLH (NIOSH)

5 mg/m3, as As

Lethal Concentration

LCLo (mice) = 2,000 mg/m3/10min

Explanatory Notes

VP = 100 mm Hg at 13.2 deg C; [HSDB] The Guide in the Emergency Response Guidebook is for "Arsenic compound, liquid, n.o.s., inorganic."

Adverse Effects
Anemia

Anemia, Aplastic

Neurotoxin

Sensorimotor Neuropathy

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Human Carcinogen

ACGIH Carcinogen

Confirmed Human

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: