Agent Name

Arsenic trioxide

CAS Number

1327-53-3

Formula

As2-O3

Major Category

Metals

Synonyms

Acide arsenieux [French]; Anhydride arsenieux [French]; Arseni trioxydum; Arsenic (III) oxide; Arsenic blanc [French]; Arsenic oxide; Arsenic oxide (As2O3); Arsenic sesquioxide; Arsenic(III) oxide; Arsenicum album; Arsenigen saure [German]; Arsenious Acid Anhydride; Arsenious acid; Arsenious oxide; Arsenious trioxide; Arsenite; Arsenolite; Arsenous acid; Arsenous acid anhydride; Arsenous anhydride; Arsenous oxide; Arsenous oxide [ISO]; Arsenous oxide anhydride; Arsentrioxide; Arsodent; Claudelite; Claudetite; Crude arsenic; Diarsenic trioxide; Oxyde Arsenieux [ISO-French]; Trisenox; UN 1561; White arsenic; [ChemIDplus] UN1561

Category

Arsenic Compounds, Inorganic

Description

Colorless or white solid; [ICSC] White powder; Soluble in water; May decompose in presence of moisture; [MSDSonline]

Sources/Uses

Uses include purification of synthesis gas, decolorizing glass, dyeing textiles (mordant), preserving hides, and preserving wood; Also used in pigments, ceramic enamels, aniline colors, herbicides, fungicides, insecticides (sheep and cattle dip), rodenticides, mineral flotation reagents, antineoplastic drugs, and growth inhibitors; [HSDB]

Comments

A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Can cause arsenic poisoning; [ICSC] Extremely toxic with an oral lethal dose of less than 5 mg/kg, or just a taste (less than 7 drops) for a 150-lb. person; [CAMEO] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis and pulmonary edema; May cause respiratory sensitization after prolonged contact; Effects in high-dose animal studies include acute pulmonary edema, cardiac arrhythmias, abnormal liver function tests, fatty liver degeneration, and depressed renal function tests; [MSDSonline] See "Arsenic" and the linked occupational diseases.

Exposure Assessment
BEI

Inorganic arsenic plus methylated metabolites in urine = 35 ug As/L; end of workweek;

TLV (ACGIH)

0.01 mg/m3, as As

PEL (OSHA)

0.01 mg/m3, as As

IDLH (NIOSH)

5 mg/m3, as As

Vapor Pressure

0.000247 mm Hg

Adverse Effects
Reproductive Toxin

Yes

Toxic Pneumonitis

Yes

Neurotoxin

Sensorimotor Neuropathy

Hepatotoxin

Hepatotoxin, Secondary

Anemia

Anemia, Aplastic

Dermatotoxin

Skin Burns

IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Human Carcinogen

ACGIH Carcinogen

Confirmed Human

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: