Agent Name

Crag herbicide

Alternative Name

Sesone

CAS Number

136-78-7

Formula

C8-H7-Cl2-O5-S.Na

Major Category

Pesticides

Synonyms

2,4-Des sodium; 2,4-Des-Na; 2,4-Des-natrium [German]; 2,4-Dichlorophenoxyethyl hydrogen sulfate sodium salt; 2,4-Dichlorophenoxyethyl sulfate, sodium salt; 2-(2,4-Dichlorfenoxy)ethylsiran sodny [Czech]; 2-(2,4-Dichlorophenoxy)ethanol hydrogen sulfate sodium salt; 2-(2,4-Dichlorophenoxy)ethyl sulfate sodium salt; Crag herbicide 1; Crag herbicide I; Disul; Disul-Na; Disul-sodium; Experimental herbicide 1; Experimental herbicide I; Herbon 2,4-des-sodium; Natrium-2,4-dichlorphenoxyathylsulfat [German]; SES; Ses-T; Sesone; Sodium 2,4-dichlorophenoxyethyl sulfate; Sodium 2,4-dichlorophenoxyethyl sulphate; Sodium 2,4-dichlorophenyl cellosolve sulfate; Sodium 2-(2,4-dichlorophenoxy)ethyl sulfate; [ChemIDplus]

Category

Herbicides, Chlorophenoxy

Description

Colorless to white crystalline, odorless solid. [herbicide]; [NIOSH]

Sources/Uses

Herbicidal pre-emergence control of annual weeds; [HSDB]

Comments

Sesone is a gastrointestinal irritant. In animal experiments, it causes liver and kidney injury. [ACGIH] "Overall, it appears that the chlorophenoxy herbicides have led to little or no hepatic injury. Where sufficient occupational exposure seems to have led to hepatic abnormalities (e.g., toxic porphyria), the presumed chemical culprit has been the contaminating TCDD, rather than the herbicide per se." [Zimmerman, p. 415] See "2,4-D."

Restricted

The production of Crag herbicide in the United States was discontinued. [ACGIH]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

Bioaccumulates

Yes

TLV (ACGIH)

10 mg/m3

PEL (OSHA)

15 mg/m3(total dust), 5 mg/m3(respirable fraction)

IDLH (NIOSH)

500 mg/m3

Excerpts from Documentation for IDLHs

Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for Crag herbicide. Therefore, the revised IDLH for Crag herbicide is 500 mg/m3 based on acute oral toxicity data in animals [Carpenter et al. 1961; Gunther 1962; Sine 1991]. This may be a conservative value due to the lack of acute toxicity data for workers.

Vapor Pressure

0.1 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: