Agent Name

Crotonaldehyde

CAS Number

4170-30-3

Formula

C4-H6-O

Major Category

Toxic Gases & Vapors

Synonyms

1-Formylpropene; 2-Butenal; 2-Butenaldehyde; AI3-18303 (USDA); Crotonal; Crotonic aldehyde; Crotylaldehyde; Krotonaldehyd [Czech]; Methylpropenal; Propylene aldehyde; UN 1143; beta-Methylacrolein; [ChemIDplus] UN1143

Category

Other Toxic Gases & Vapors

Description

Water-white liquid with a suffocating odor; Note: Turns pale-yellow on contact with air; [NIOSH]

Sources/Uses

Used in the synthesis of other organic chemicals; [ACGIH]

Comments

Rats exposed to 1500 ppm, a lethal concentration, develop pulmonary edema. [ACGIH] Liquid causes second degree burns after contact for a few minutes. [CHRIS] Also CAS # 123-73-9; A lachrymator; [CHEMINFO] Corrosive to the eyes; Causes lachrymation; Can cause pulmonary edema; [ICSC]

Reference Link

ATSDR Medical Management - Crotonaldehyde

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

Ceiling (ACGIH)

0.3 ppm

PEL (OSHA)

2 ppm

IDLH (NIOSH)

50 ppm

Excerpts from Documentation for IDLHs

Human data: Exposure to 4.1 ppm for 15 minutes was highly irritating to the nose and upper respiratory tract and produced lacrimation in 30 seconds [Sim and Pattle 1957]. In another study, exposures to 45 ppm proved very disagreeable after a few seconds, with conjunctival irritation evident [Rinehart 1967].

Vapor Pressure

30 mm Hg

Odor Threshold Low

0.06 ppm

Odor Threshold High

0.2 ppm

RD50

3 ppm

Lethal Concentration

LC50 (rat) = 200 mg/m3/2H

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.11 ppm); The Guide from the Emergency Response Guidebook is for "crotonaldehyde, inhibited." Flash point = 13 deg C;

Reference Link

ICSC: Crotonaldehyde

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: