Agent Name

Azaserine

CAS Number

115-02-6

Formula

C5-H7-N3-O4

Major Category

Biological Agents

Synonyms

AZS; Acetic acid, diazo-, ester with serine; Azaserin; Azaserina [INN-Spanish]; Azaserinum [INN-Latin]; CL 337; CN 15757; CN-15,757; Diazoacetate (ester) L-serine; L-Azaserine; L-Serine, diazoacetate (ester); L-beta-(Diazoacetoxy)alanin; O-Diazoacetyl-L-serine; P-165; Serine, diazoacetate (ester), L-; [ChemIDplus] UN3462

Category

Bacterial Toxins

Description

Light yellow-green solid; [Merck Index] Faintly yellow powder; [MSDSonline]

Sources/Uses

Antitumor/antibiotic produced by Streptomyces sp; Used to induce pancreatic cancer in laboratory animals; [Merck Index] Medical and veterinary applications include: antibiotic, antifungal, antineoplastic, and immunosuppressive; Not commercially produced in the US; [HSDB]

Comments

An amino acid antagonist that inhibits the synthesis of proteins and nucleic acids; Causes fatty liver and hepatic necrosis; Emergency treatment: Symptomatic drug ingestion; [HSDB] May cause irritation; Targets kidneys, liver, and bone marrow; [MSDSonline]

Exposure Assessment
Vapor Pressure

1.53E-10 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Possible Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.