Agent Name

Crufomate

CAS Number

299-86-5

Formula

C12-H19-Cl-N-O3-P

Major Category

Pesticides

Synonyms

2-Chloro-4-(1,1-dimethylethyl)phenyl methyl methylphosphoramidate; 4-Tert. butyl 2-chlorophenyl methylphosphoramidate de methyle [French]; 4-t-Butyl-2-chlorophenyl methyl methylphosphoramidate; 4-t-Butyl-2-chlorophenylmethyl methyl phosphoramidate; 4-tert-Butyl-2-chlorophenyl N-methyl O-methylphosphoramidate; 4-tert-Butyl-2-chlorophenyl O-methyl methylphosphoroamidate; 4-tert-Butyl-2-chlorophenyl methyl methylphosphoramidate; 4-tert. Butyl 2-chlorophenyl methylphosphoramidate de methyle [French]; Amidofos; Amidophos; Crufomate A; Crufomate [ANSI]; Crufomato [INN-Spanish]; Crufomatum [INN-Latin]; Dowco 132; M-1261; Methylphosphoramidic acid 2-chloro-4-(1,1-dimethylethyl)phenyl methyl ester; Methylphosphoramidic acid, 4-t-butyl-2-chlorophenyl methyl ester; Montrel; N,O-Dimethyl-o-(4-tert-butyl-2-chlorophenyl)phosphoramidate; O-(4-Tert butyl-2-chloor-fenyl)-O-methyl-fosforzuur-N-methyl-amide [Dutch]; O-(4-Tert-butyl-2-chlor-phenyl)-O-methyl-phosphorsaeure-N-methylamid [German]; O-(4-Terz.-butil-2-cloro-fenil)-O-metil-fosforammide [Italian]; O-(4-tert Butyl-2-chloor-fenyl)-O-methyl-fosforzuur-N-methyl-amide [Dutch]; O-(4-tert-Butyl-2-chlor-phenyl)-O-methyl-phosphorsaeure-N-methylamid [German]; O-(4-tert-Butyl-2-chlorophenyl) O-methyl N-methylamido phosphate; O-Methyl O-2-chloro-4-tert-butylphenyl N-methylamidophosphate; O-Methyl-O-(4-tert-butyl-2-chlorophenyl)methylphosphoramidate; Phenol, 4-t-butyl-2-chloro-, ester with methyl methylphosphoramidate; Phosphoramidic acid, 4-tert-butyl-2-chlorophenylphosphoramidate; Phosphoramidic acid, methyl-, 2-chloro-4-(1,1-dimethylethyl)phenyl methyl ester; Phosphoramidic acid, methyl-, 4-tert-butyl-2-chlorophenyl methyl ester; Ruelene; Ruelene 25E; Ruelene drench; Rulene; [ChemIDplus]

Category

Organophosphate Insecticides

Description

White, crystalline solid in pure form. [pesticide] [Note: Commercial product is a yellow oil.]; [NIOSH]

Sources/Uses

Used to kill cattle lice, grubs, and horn flies; [HSDB]

Comments

A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; [ICSC] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

5 mg/m3

Vapor Pressure

3.75E-5 mm Hg

Lethal Concentration

LCLo (rat) = 12 mg/m3/4h

Adverse Effects
Other Poison

Organophosphate

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: