Agent Name

Azoxybenzene

CAS Number

495-48-7

Formula

C12-H10-N2-O

Major Category

Nitrogen Compounds

Synonyms

Azobenzene, oxide; Azossibenzene [Italian]; Azoxybenzeen [Dutch]; Azoxybenzide; Azoxybenzol [German]; Azoxydibenzene; Benzene, azoxydi-; Diazene, diphenyl-, 1-oxide; Diphenyldiazene 1-oxide; Fenazox [German]; Fentoxan; Ordinary azoxybenzene; [ChemIDplus]

Category

Other Aromatics (Nitrogen)

Description

Yellow solid; mp = 36 deg C; [HSDB] Bright yellow or yellowish-brown solid; mp = 36 deg C; [CAMEO] Orange solid; mp = 33-36 deg C; [Alfa Aesar MSDS]

Sources/Uses

Used as an intermediate for dyes, an insecticide, and an agent for diagnosis and control of varroa jacobsoni and acarapis woodi on bees; [HSDB]

Comments

External application to rabbit eyes scored 1 on a scale of 1-10 (10 being most severe) for degree of injury after 24 hours; Causes icteric skin, methemoglobinemia, swelling of liver and spleen, and atrophy of testis and epididymis in oral studies of rats and mice; Emergency treatment: Methemoglobinemia; [HSDB] Dust mixtures with air may be explosive; A skin and eye irritant; May cause liver and kidney injury; [CAMEO] Causes decrease in cellular immune response in intraperitoneal toxic-dose studies of rats; Causes other GI and liver changes in oral lethal-dose studies of mice; [RTECS] May cause irritation and methemoglobinemia; [Alfa Aesar MSDS]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

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