Agent Name

Cumene

CAS Number

98-82-8

Formula

C9-H12

Major Category

Solvents

Synonyms

(1-Methylethyl)benzene; 2-Fenilpropano [Italian]; 2-Fenyl-propaan [Dutch]; 2-Phenylpropane; Benzene, isopropyl; CUMENE; Cumeen [Dutch]; Cumol; Isopropilbenzene [Italian]; Isopropyl-benzol [German]; Isopropylbenzeen [Dutch]; Isopropylbenzene; Isopropylbenzol; Propane, 2-phenyl; [ChemIDplus] UN1918

Category

Aromatic Solvents

Description

Colorless liquid with a sharp, penetrating, aromatic odor; [NIOSH]

Sources/Uses

Used in surface coatings and high-octane aviation fuel; [ACGIH]

Comments

Liver toxicity occurs in rats inhaling 500 ppm daily for 5 months. [ACGIH] Inhalation of high concentrations may cause CNS effects; A skin, eye, and respiratory tract irritant; [ICSC] Fatty liver changes are noted in animals exposed to lethal doses; [HSDB]

Reference Link

IARC 2012: Cumene

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

50 ppm

PEL (OSHA)

50 ppm

MAK

10 ppm

IDLH (NIOSH)

900 ppm

Excerpts from Documentation for IDLHs

Daily exposures of rats to 500 ppm for 5 months resulted in no significant blood changes, although hyperemia and congestion were noted in the lungs, liver, and kidneys [Clayton and Clayton 1981].

Vapor Pressure

4.5 mm Hg

Odor Threshold Low

0.008 ppm

Odor Threshold High

0.13 ppm

Lethal Concentration

LCLo (rat) = 8,000 ppm/4H

Explanatory Notes

IDLH = 10% LEL (lower explosive limit); Detection odor threshold from AIHA (mean = 0.032 ppm); Flash point = 39 deg C; See "2017 Notice of Intended Changes." [TLVs and BEIs]

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: