Agent Name

Cyclohexane

CAS Number

110-82-7

Formula

C6-H12

Major Category

Solvents

Synonyms

Benzene, hexahydro-; Benzenehexahydride; Cicloesano [Italian]; Cyclohexaan [Dutch]; Cyclohexan [German]; Cyclohexane; Cykloheksan [Polish]; Hexahydrobenzene; Hexamethylene; Hexanaphthene; [ChemIDplus] UN1145

Category

Aliphatics, Saturated (<C12)

Description

Colorless liquid with a sweet, chloroform-like odor; Note: A solid below 44 degrees F; [NIOSH]

Sources/Uses

Used as a paint remover, solvent for surface coatings, and intermediate for organic synthesis; [ACGIH]

Comments

Exposed animals develop narcosis and minimal histopathological liver changes. The odor threshold was found to be 25 ppm and 300 ppm by 2 different investigators. [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

No

TLV (ACGIH)

100 ppm

PEL (OSHA)

300 ppm

MAK

200 ppm

IDLH (NIOSH)

1300 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on a statement by Patty [1963] that 12,600 ppm produced evidence of lethargy, narcosis, increased respiration rate, and convulsions in animals [Treon et al. 1943]. Also, AIHA [1963] reported that 9,300 ppm for 30 minutes resulted in restlessness, impaired coordination, and exhaustion, but no narcosis or deaths in cats, rabbits, and pigs [Flury and Zernik 1931]. . . . Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in animals [Lazarew 1929; Treon et al. 1943], a value of about 3,000 ppm would have been appropriate. However, the revised IDLH for cyclohexane is 1,300 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 1.3%).

Vapor Pressure

96.9 mm Hg

Odor Threshold Low

0.52 ppm

Odor Threshold High

784 ppm

Lethal Concentration

LCLo (mice) = 70,000 mg/m3/2H

Explanatory Notes

IDLH = 10% LEL; Detection odor threshold from AIHA (mean = 780 ppm); Flash point = -4 deg F;

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

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Diseases

Occupational diseases associated with exposure to this agent:

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