Agent Name

beta-Cadinene

CAS Number

523-47-7

Formula

C15-H24

Major Category

Biological Agents

Synonyms

Cadina-3,9-diene; Cadine-3,9-diene; Naphthalene, 1,2,4a,5,8,8a-hexahydro-4,7-dimethyl-1-(1-methylethyl)-, (1S-(1alpha,4abeta,8aalpha))-; beta-Cadinene, (-)-; [ChemIDplus]

Category

Wood Dusts & Extracts

Description

Oil with a pleasant odor; Insoluble in water; [HSDB]

Sources/Uses

Used in fragrances and flavors; [HSDB] Found in cade oil and cedarleaf oil (wood oils); [CAMEO]

Comments

10% in petrolatum produced no skin irritation or sensitization in 25 volunteers; Cadinene: LD50 oral (rat) > 5,000 mg/kg; LD50 dermal (rabbit) > 5,000 mg/kg; Emergency treatment: "Essential oils"; Essential oils can cause CNS depression and aspiration pneumonia after ingestion; Commercial products of essential oils usually contain concentrations of 1% to 20%, and a potentially toxic exposure is 5-15 mL; [HSDB] An eye irritant; [CAMEO] Safe when used as a flavoring agent in food; [JECFA]

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

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Diseases

Occupational diseases associated with exposure to this agent: