Agent Name

Di-sec-octyl phthalate

Alternative Name

DEHP

CAS Number

117-81-7

Formula

C24-H38-O4

Major Category

Plastics & Rubber

Synonyms

DEHP; Diethylhexyl phthalate; Di(2-ethylhexyl)phthalate; Bis(2-ethylhexyl) 1,2-benzenedicarboxylate; Bis(2-ethylhexyl) phthalate; Bis-(2-ethylhexyl)ester kyseliny ftalove [Czech]; Bisoflex 81; Bisoflex DOP; Celluflex DOP; Compound 889; DEHP; DOF [Russian plasticizer]; Di(2-ethylhexyl) orthophthalate; Di(2-ethylhexyl) phthalate; Di(2-ethylhexyl)orthophthalate; Di(2-ethylhexyl)phthalate; Diacizer DOP; Diethylhexyl phthalate; Dioctyl phthalate; Ergoplast FDO; Ergoplast FDO-S; Etalon; Etalon (plasticizer); Ethylhexyl phthalate; Eviplast 80; Eviplast 81; Fleximel; Flexol DOP; Flexol Plasticizer DOP; Good-rite GP 264; Hatcol DOP; Hercoflex 260; Jayflex DOP; Kodaflex DEHP; Kodaflex DOP; Mollan O; Monocizer DOP; Nuoplaz DOP; Octoil; PX-138; Palatinol AH; Pittsburgh PX-138; Plasthall DOP; Platinol AH; Platinol DOP; RC Plasticizer DOP; Reomol D 79P; Reomol DOP; Sansocizer DOP; Sansocizer R 8000; Sconamoll DOP; Sicol 150; Staflex DOP; Truflex DOP; Vestinol AH; Vinicizer 80; Witcizer 312; [ChemIDplus]

Category

Phthalate Esters

Description

Colorless, oily liquid with a slight odor; [NIOSH]

Sources/Uses

Used as a plasticizer; also used in pesticides (an inert ingredient), dielectric fluids, erasable inks, and vacuum pump oils; [ACGIH]

Comments

". . . Low toxicity by all routes of exposure. . ." [ACGIH] In inhalation studies of rats, no harmful effects were found. High-dose feeding studies of mice showed reversible sperm injury; also liver damage occurred. DEHP is not readily absorbed through the skin. [ATSDR ToxFAQs] In high-dose reproductive studies of rats and mice, DEHP and other phthalates cause testicular damage to males and increased fetal losses and malformations to pregnant females. [Frazier, p. 350-2] Occupational asthma in a PVC production worker was confirmed by PEF measurements. [Malo] Causes contact urticaria; [Kanerva, p. 219] See "PHTHALATE ESTERS."

Reference Link

Occupational asthma caused by dioctyl-phthalate in a bottle cap production worker

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

5 mg/m3

PEL (OSHA)

5 mg/m3

MAK

2 mg/m3, inhalable fraction

IDLH (NIOSH)

5000 mg/m3

Excerpts from Documentation for IDLHs

Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for disec octyl phthalate. Since the acute oral toxicity data in animals [Autian 1973; Shibko and Blumenthal 1973; Yagi et al. 1976] indicates that disec octyl phthalate has low acute toxicity, the revised IDLH for disec octyl phthalate is 5,000 mg/m3 based on being 1,000 times the OSHA PEL of 5 mg/m3 . . .

Vapor Pressure

1.42E-7 mm Hg

Explanatory Notes

Flash point = 405 deg F;

Reference Link

ATSDR - ToxFAQs - Di(2-ethylhexyl)phthalate (DEHP)

Adverse Effects
Asthma

Yes

Reproductive Toxin

Yes

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: