Agent Name

Dibutyl phthalate

Alternative Name

Di-n-butyl phthalate

CAS Number

84-74-2

Formula

C16-H22-O4

Major Category

Plastics & Rubber

Synonyms

Di-n-butyl phthalate; 1,2-Benzenedicarboxylic acid, dibutyl ester; AI-3-00283; Benzene-o-dicarboxylic acid di-n-butyl ester; Butyl phthalate; Celluflex DPB; DBP; DBP (ester); Di-n-butyl phthalate; Di-n-butylester kyseliny ftalove [Czech]; Dibutyl 1,2-benzenedicarboxylate; Dibutyl phthalate; Dibutyl-o-phthalate; Elaol; Ergoplast FDB; Ersoplast FDA; Genoplast B; Hatcol DBP; Hexaplas M/B; Kodaflex DBP; N-Butylphthalate; PX 104; Palatinol C; Phthalate, di-n-butyl; Phthalate, dibutyl-; Polycizer DBP; RC Plasticizer DBP; Staflex DBP; Uniflex DBP; Unimoll db; Witcizer 300; n-Butyl phthalate; o-Benzenedicarboxylic acid, dibutyl ester; [ChemIDplus] UN9095

Category

Phthalate Esters

Description

Colorless to faint-yellow, oily liquid with a slight, aromatic odor; [NIOSH]

Sources/Uses

Plasticizer (added to polymers to effect flexibility and/or toughness); also used as an insect repellant in clothing and a solvent for perfumes, oils, and textiles; [ACGIH] Used in epoxy resins as a non-reactive solvent; [Kanerva, p. 1779]

Comments

The heated compound is an irritant to the eyes and respiratory tract. [ACGIH] Allergic contact dermatitis reported in workers handling epoxy resins; [Kanerva, p. 1779] Causes contact urticaria; [Kanerva, p. 219] In high-dose reproductive studies of rats and mice, DEHP and other phthalates cause testicular damage to males and increased fetal losses and malformations to pregnant females. [Frazier, p. 350-2]

Reference Link

Allergic contact dermatitis from dibutyl phthalate, propyl gallate and hydrocortisone in Timodine (No Abstract Available)

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

5 mg/m3

PEL (OSHA)

5 mg/m3

MAK

0.58 mg/m3(can also occur as vapor and aerosol)

IDLH (NIOSH)

4000 mg/m3

Excerpts from Documentation for IDLHs

The revised IDLH for dibutyl phthalate is 4,000 mg/m3 based on acute inhalation toxicity data in animals [Izmerov et al. 1982]. [Note: Due to its low volatility, this concentration could only be reached at elevated temperatures or if the liquid droplets become airborne as in a mist.]

Vapor Pressure

2.01E-5 mm Hg

Lethal Concentration

LC50 (mice) = 25,000 mg/m3/2H

Explanatory Notes

Flash point = 315 deg F;

Half Life

Whole body (animal studies): virtually all eliminated within 48 hours; [TDR, p. 473]

Reference Link

ICSC: Dibutyl phthalate

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: