Agent Name

Silver

Alternative Name

Silver metal and soluble compounds

CAS Number

7440-22-4; varies

Formula

Ag, varies

Major Category

Metals

Synonyms

Silver metal: Argentum; Silver compounds; [NIOSH] Silver metal and soluble compounds;

Category

Metals, Inorganic Compounds

Description

Metal: White, lustrous solid; [NIOSH]

Sources/Uses

Used in brazes, solders, coins, jewelry, tableware, photography, photochromic glass, electrical contacts, electroplating, electroless plating, magnetron sputtered reflective coatings, dental amalgams, jet engine bearings; Silver nanoparticle applications include impregnating anti-bacterial wound dressings, intraventricular catheters, surgical tools, toothbrushes, infant pacifiers, sanitizing sprays, and home purification systems; Also used in electronics, metallurgy, and catalysis; [HSDB] Nanoparticles also used in bedding, water purification, kitchen utensils, toys, and humidifiers; [PMID 21191487]

Comments

Silver nitrate, used in burn therapy, is a reported inducer of methemoglobinemia. [ATSDR Case Studies, # 16] In the past, acute renal failure was reported in film developers after exposure to soluble silver compounds. [Rosenstock, p. 574] Argria is a blue-gray discoloration of the skin or mucous membranes; it has been described in humans mainly after injection or ingestion of silver-containing medications. Argyria has also been described in workers exposed to high levels of silver inhaled as dusts or mists: silver reclamation, photographic processing (silver nitrate), silver refineries, varnish spraying, and silver polishing. [ACGIH] Soluble silver compounds include nitrates, acetates, sulfates, and salts of Na, K, and ammonium; Insoluble silver compounds include chlorides, bromides, iodides, hydroxides, carbonates, and phosphates; [Nordberg, p. 19]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

Bioaccumulates

Yes

TLV (ACGIH)

0.01 mg/m3, as Ag (compounds), 0.1 mg/m3 dust and fume (metal)

PEL (OSHA)

0.01 mg/m3, as Ag

MAK

0.1 mg/m3, inhalable fraction (metal)

IDLH (NIOSH)

10 mg/m3, as Ag

Excerpts from Documentation for IDLHs

Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for silver (metal dust and soluble compounds). Therefore, the revised IDLH for silver (metal dust and soluble compounds) is 10 mg Ag/m3 based on acute oral toxicity data in humans [Arena 1970] and animals [Flury and Zernik 1935].

Half Life

No reports found; [TDR, p. 1083]

Reference Link

ATSDR - ToxFAQs - Silver

Adverse Effects
Nephrotoxin

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: