Agent Name

2,2-Bis(bromomethyl)-1,3-propanediol

CAS Number

3296-90-0

Formula

C5-H10-Br2-O2

Major Category

Other Classes

Synonyms

1,3-Dibromo-2,2-dimethylolpropane; 1,3-Propanediol, 2,2-bis(bromomethyl)-; 2,2-Dibromomethyl-1,3-propanediol; Dibromoneopentyl glycol; Dibromopentaerythritol; FR 1138; Pentaerythritol dibromide; Pentaerythritol dibromohydrin; 2,2-Bis(bromomethyl)propane-1,3-diol; [ChemIDplus]

Category

Halogenated Alcohols

Description

Off-white hygroscopic solid; [CAMEO]

Sources/Uses

Used as a reactive flame retardant for epoxy, polyester, and urethane foams and a chemical intermediate for flame retardants; [HSDB]

Comments

A skin, eye, and mucous membrane irritant; May cause liver damage and corneal injury; [CAMEO] Observations in a high-dose lifetime feeding study of rats include degenerative changes to liver and eyes, but no oncogenic reaction; A two year feeding study with rats produced increase in neoplasm frequency in various tissues and organs; [HSDB] Effects observed in 13 week oral studies with mice and rats include histopathological changes to kidneys and urinary bladder; Rats fed 100 mg/kg bw throughout their lifetime exhibited degeneration of the liver, eye, and higher frequency of thyroid retention cyst formation; No adverse effects on sperm parameters or estrous cycle observed in 13 week feeding studies with rats and mice; A decrease in female reproductive capacity was shown in a continuous breeding study with mice; Some evidence of mutagenicity; Sufficient evidence of carcinogenicity in laboratory animals; [IARC]

Exposure Assessment
WEEL

0.2 mg/m3

Vapor Pressure

1.3E-5 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.