Agent Name

Brucine

CAS Number

357-57-3

Formula

C23-H26-N2-O4

Major Category

Biological Agents

Synonyms

(-)-Brucine; 10,11-Dimethoxystrychnine; 2,3-Dimethoxy-strychnine; 2,3-Dimethoxystrychnidin-10-one; 2,3-Dimethoxystrychnine; Brucin [German]; Brucina [Italian]; Brucine alkaloid; Brucinum; Bruzin; Dimethoxy strychnine; Strychnidin-10-one, 2,3-dimethoxy-; Strychnine, 2,3-dimethoxy-; [ChemIDplus] UN1570

Category

Plant Toxins

Description

Colorless or white odorless solid; Slightly soluble in water (3.2 g/L at 15 deg C); [HSDB] White powder; [MSDSonline]

Sources/Uses

Extracted from the seeds and bark of Strychnos aculeata; Used for denaturing alcohol and oils; Also used as an additive to lubricants, a rodent poison, a CNS stimulant, and a chemical reagent; [HSDB] A poison resembling strychnine that is much less potent; [Reference #1]

Comments

An eye, nose and throat irritant; [HSDB] Oral LD50 (mouse) = 150 mg/kg; [RTECS] May cause convulsions and respiratory paralysis; [ICSC] An irritant; Effects in high-dose animal studies include convulsions; [MSDSonline]

Reference Link

INCHEM: Brucine (PIM 082)

Exposure Assessment
Vapor Pressure

3.13E-10 mm Hg

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: