Agent Name

p-Dichlorobenzene

Alternative Name

1,4-Dichlorobenzene

CAS Number

106-46-7

Formula

C6-H4-Cl2

Major Category

Pesticides

Synonyms

p-DCB; para-Dichlorobenzene; Dichlorocide; 1,4-Dichlorobenzene; [NIOSH]

Category

Fumigants

Description

Colorless or white crystalline solid with a mothball-like odor. [insecticide]; [NIOSH]

Sources/Uses

Used as an insecticide and fumigant; [ACGIH] Used as a deodorizer for toilets and garbage cans; Also used as a moth repellent and chemical intermediate; [CHEMINFO]

Comments

After daily doses of 500 mg/kg, rats develop focal hepatic necrosis. TLV Basis: eye irritation and kidney damage; Humans report eye irritation at 17 ppm and higher. Renal toxicity is observed in animal experiments at 25 ppm and higher. Hemolytic anemia and jaundice have been reported after ingestion. [ACGIH] Experimental animals suffer CNS depression and liver and kidney damage after high-dose inhalation studies. [CHEMINFO] Suspected germ cell mutagen (3B); [MAK]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

10 ppm

PEL (OSHA)

75 ppm

IDLH (NIOSH)

150 ppm

Excerpts from Documentation for IDLHs

No adverse effects were noted in a workplace averaging 105 ppm (range 50 to 170 ppm), but painful irritation of the eyes and nose was found at 80 to 160 ppm, and breathing was difficult at concentrations greater than 160 ppm [Hollingsworth et al. 1956].

Vapor Pressure

1.3 mm Hg

Odor Threshold Low

0.12 ppm

Odor Threshold High

15 ppm

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.12 ppm); Melting point = 53 deg C; [CHEMINFO]

Reference Link

ATSDR - ToxFAQs - Dichlorobenzenes

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: